Absorption Characteristics of Dextrans with Different Molecular Weights from the Liver Surface Membrane in Rats: Its Implication for Targeting to the Liver Abbreviated title for running headlines DEXTRAN ABSORPTION FROM LIVER SURFACE
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چکیده
منابع مشابه
[Development of drug delivery system by utilizing absorption from liver surface and its application].
Because it is difficult to achieve local drug activity following administration by the conventional intravenous and oral routes, I sought to develop a new route of administration utilizing drug absorption from the liver surface in order to target that organ. Although direct application to the liver surface should yield local drug distribution, drug absorption from the liver surface has not been...
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We have examined the influence of liver disease on drug absorption from the liver surface membrane, regarded as the first barrier for drug targeting to the liver. The main purpose of this study is to examine the possibility of direct liver surface application as a drug targeting method. We employed rats intoxicated with carbon tetrachloride (CCl(4)) or D-galactosamine (GAL) as the liver disease...
متن کاملAbsorption characteristics of compounds with different molecular weights after application to the unilateral kidney surface in rats.
The aim of the present study is to clarify the absorption mechanism of a drug from the kidney surface membrane in rats. We studied the absorption characteristics of phenolsulfonphthalein (PSP) and other compounds with different molecular weights after their application to the rat kidney surface in vivo, employing a cylindrical diffusion cell (i.d. 6 mm, area 0.28 cm(2)). The time course of free...
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The aim of the present study was to determine the levels of cadmium in the muscle, liver and kidney of cattle from Isfahan and to compare the results with those reported by other countries and with the maximum acceptable levels for human consumption. Samples of muscle, liver and kidney from 60 animals aged 1–10- year-old were collected from the carcasses slaughtered at Isfahan abattoir. Samples...
متن کاملEnhanced Therapeutic Benefit of QuercetinPhospholipid Complex in Carbon Tetrachloride-Induced Acute Liver Injury in Rats: A Comparative Study
Quercetin is a typical flavonoid with diverse biological effects, attributable to its free radical scavenging activity. Bioavailability of quercetin aglycone and its glycosides is an important factor for its antioxidant activity in vivo. A severe limitation exists and is imputable to very poor absorption of quercetin when administered orally. To overcome this limitation, development of a value ...
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تاریخ انتشار 2017